Virginia L. Miller Explained

Virginia Miller
Thesis Title:Analysis of the cholera toxin positive regulatory gene, toxR
Thesis Url:https://www.worldcat.org/oclc/
Thesis Year:1985

Virginia L. Miller is a microbiologist known for her work on studying the factors leading to disease caused by bacteria. Miller is an elected fellow of the American Academy of Microbiology (2003) and a former Pew Charitable Trust Biomedical Scholar (1989).[1]

Education and career

Miller has a B.A. from the University of California, Santa Barbara (1979).[2] She earned her Ph.D. from Harvard University in 1985 where she worked on the expression of genes associated with Cholera toxin.[3] Following her Ph.D., she was a postdoc at Stanford University.[4] She moved to the University of California, Los Angeles in 1988 and earned tenure in 1994.[5] She moved to Washington University in St. Louis in 1996, and then to the University of North Carolina at Chapel Hill in 2008. As of 2021, Miller is a professor of genetics, microbiology, and immunology at the University of North Carolina at Chapel Hill.

Research

Miller is known for her research into bacterial pathogenesis, the factors leading to the onset of disease from specific species of bacteria.[6] [7] [8] [9] [10] Her early research examined the synthesis of the cholera toxin by Vibrio cholerae[11] [12] and identified environmental signals that lead V. cholerae to express the proteins needed to make the cholera toxin.[13] She went on to examine the mechanisms by which another bacteria pathogen - Yersinia pestis - enters cells[14] and cause disease.[15] She has also worked on how Salmonella[16] [17] and Klebsiella pneumoniae[18] [19] cause disease. In brief, she mostly worked in the areas of Microbiology, Yersinia enterocolitica and Virulence.[20]

Awards and honors

In 1989, Miller was named a Pew Scholar. In 2003, Miller was elected a fellow of the American Academy of Microbiology.[21]

Selected publications

Notes and References

  1. Web site: Virginia L. Miller, PhD. 2022-03-16. PEW Trusts - Biomedical Scholars (1989). en-US.
  2. Web site: Virginia Miller, PhD. 2021-12-04. Institute for Global Health and Infectious Diseases. en-US.
  3. Analysis of the cholera toxin positive regulatory gene, toxR. 1985. English. Virginia L. Miller. 17572198.
  4. Web site: Virginia Miller, Ph.D.. 2021-11-30. ASM.org. en.
  5. Web site: 2014-02-23. Miller biographical sketch. live. 2021-12-04. https://web.archive.org/web/20140223041120/https://globalhealth.unc.edu/wp-content/uploads/2013/09/V-Miller-biosketch-07-ID-TG.pdf. 2014-02-23.
  6. Schmiel . Deborah H. . Miller . Virginia L. . 1999-11-01 . Bacterial phospholipases and pathogenesis . Microbes and Infection . en . 1 . 13 . 1103–1112 . 10.1016/S1286-4579(99)00205-1 . 10572314 . 1286-4579. free .
  7. Pepe . J C . Wachtel . M R . Wagar . E . Miller . V L . December 1995 . Pathogenesis of defined invasion mutants of Yersinia enterocolitica in a BALB/c mouse model of infection . Infection and Immunity . en . 63 . 12 . 4837–4848 . 10.1128/iai.63.12.4837-4848.1995 . 0019-9567 . 173693 . 7591144.
  8. Young . Glenn M. . Miller . Virginia L. . July 1997 . Identification of novel chromosomal loci affecting Yersinia enterocolitica pathogenesis . Molecular Microbiology . en . 25 . 2 . 319–328 . 10.1046/j.1365-2958.1997.4661829.x. 9282744 . 25748196 . free .
  9. Young . G M . Amid . D . Miller . V L . November 1996 . A bifunctional urease enhances survival of pathogenic Yersinia enterocolitica and Morganella morganii at low pH . Journal of Bacteriology . en . 178 . 22 . 6487–6495 . 10.1128/jb.178.22.6487-6495.1996 . 0021-9193 . 178535 . 8932305.
  10. Weening . Eric H. . Cathelyn . Jason S. . Kaufman . Greer . Lawrenz . Matthew B. . Price . Paul . Goldman . William E. . Miller . Virginia L. . February 2011 . Camilli . A. . The Dependence of the Yersinia pestis Capsule on Pathogenesis Is Influenced by the Mouse Background . Infection and Immunity . en . 79 . 2 . 644–652 . 10.1128/IAI.00981-10 . 0019-9567 . 3028848 . 21115720.
  11. Miller. V. L.. Mekalanos. J. J.. 1984-06-01. Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR.. Proceedings of the National Academy of Sciences. en. 81. 11. 3471–3475. 10.1073/pnas.81.11.3471. 0027-8424. 345530. 6374658. 1984PNAS...81.3471M. free.
  12. Miller. Virginia L.. Taylor. Ronald K.. Mekalanos. John J.. 1987. Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein. Cell. en. 48. 2. 271–279. 10.1016/0092-8674(87)90430-2. 3802195. 28576010.
  13. Miller. V L. Mekalanos. J J. 1988-06-01. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. Journal of Bacteriology. 170. 6. 2575–2583. 10.1128/jb.170.6.2575-2583.1988. 211174. 2836362.
  14. Miller. V L. Falkow. S. 1988. Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells. Infection and Immunity. en. 56. 5. 1242–1248. 10.1128/iai.56.5.1242-1248.1988. 2833444. 259798. 0019-9567.
  15. Miller. V L. Farmer. J J. Hill. W E. Falkow. S. 1989. The ail locus is found uniquely in Yersinia enterocolitica serotypes commonly associated with disease. Infection and Immunity. en. 57. 1. 121–131. 10.1128/iai.57.1.121-131.1989. 2642465. 313052. 0019-9567.
  16. Hong. K. Heran. Miller. Virginia L.. 1998. Identification of a Novel Salmonella Invasion Locus Homologous to Shigella ipgDE. Journal of Bacteriology. en. 180. 7. 1793–1802. 10.1128/JB.180.7.1793-1802.1998. 9537377. 107092. 0021-9193.
  17. Darwin. K. Heran. Miller. Virginia L.. 1999. Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa. Clinical Microbiology Reviews. en. 12. 3. 405–428. 10.1128/CMR.12.3.405. 10398673. 100246. 0893-8512.
  18. Lawlor. Matthew S.. Hsu. James. Rick. Paul D.. Miller. Virginia L.. 2005. Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model: Klebsiella pneumoniae intranasal STM. Molecular Microbiology. en. 58. 4. 1054–1073. 10.1111/j.1365-2958.2005.04918.x. 16262790. 44666800. free.
  19. Lawlor. Matthew S.. O'Connor. Christopher. Miller. Virginia L.. 2007. Yersinia bactin Is a Virulence Factor for Klebsiella pneumoniae during Pulmonary Infection. Infection and Immunity. en. 75. 3. 1463–1472. 10.1128/IAI.00372-06. 0019-9567. 1828572. 17220312.
  20. Web site: Virginia L. Miller: H-index & Awards - Academic Profile . 2022-07-29 . Research.com . en.
  21. Web site: American Academy of Microbiology fellows. December 3, 2021.

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