Virgilio Mazzocchi (22 July 1597 bapt. - 3 October 1646) was an Italian baroque composer.
He was born in Veja, near Civita Castellana, where he was baptized, as the younger brother of the more famous composer and learned lawyer Domenico Mazzocchi. Like his brother, who shared some features of his career, he was largely a composer of sacred vocal music. Mazzocchi is associated with providing music for the papal chapels. He died in Civita Castellana, where he had gone with his singers to celebrate the holy patrons, after a sudden illness.