Viqualine Explained

Viqualine (INN) (developmental code name PK-5078) is an antidepressant and anxiolytic drug that was never marketed.^{[1] [2] [3]} It acts as a potent and selective serotonin releasing agent and serotonin reuptake inhibitor.^[4] In addition, viqualine displaces diazepam from the GABA_A receptor and produces benzodiazepine-like effects, indicating that it is also a positive allosteric modulator of the benzodiazepine site of the GABA_A receptor.^[5] The drug has mainly been researched as a potential treatment for alcoholism.^{[6] [7]}

See also

• Indalpine
• Pipequaline

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 1–.
2. Faravelli C, Albanesi G, Sessarego A . Viqualine in resistant depression: a double-blind, placebo-controlled trial . Neuropsychobiology . 20 . 2 . 78–81 . 1988 . 3075725 . 10.1159/000118477 .
3. Book: Papakostas GI, Fava M . Pharmacotherapy for Depression and Treatment-resistant Depression. 2010. World Scientific. 978-981-4287-59-3. 304–.
4. Le Fur G, Imbault F, Mitrani N, Marquis F, Renault C, Dubroeucq MC, Gueremy C, Uzan A . 6 . The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives . Neuropharmacology . 23 . 2A . 169–173 . February 1984 . 6717757 . 10.1016/S0028-3908(84)80010-6 . 30380886 .
5. Faravelli C, Albanesi G, Sessarego A . Viqualine in resistant depression: a double-blind, placebo-controlled trial . Neuropsychobiology . 20 . 2 . 78–81 . 1988 . 3075725 . 10.1159/000118477 .
6. Book: Naranjo CA, Sellers EM . Recent Developments in Alcoholism . Serotonin Uptake Inhibitors Attenuate Ethanol Intake in Problem Drinkers . 7 . 255–266 . 1989 . 2522667 . 10.1007/978-1-4899-1678-5_13 . 978-1-4899-1680-8 .
7. Naranjo CA, Sullivan JT, Kadlec KE, Woodley-Remus DV, Kennedy G, Sellers EM . Differential effects of viqualine on alcohol intake and other consummatory behaviors . Clinical Pharmacology and Therapeutics . 46 . 3 . 301–309 . September 1989 . 2673621 . 10.1038/clpt.1989.142 . 27080094 .