Villonodular synovitis explained

Villonodular synovitis is a type of synovial swelling.

Types include:

• Pigmented villonodular synovitis
• Giant cell tumor of the tendon sheath

Though they have very different names, they have the same histology, and stain positive for CD68, HAM56, and vimentin.^[1] They are sometimes discussed together.^{[2] [3] [4]}

Notes and References

1. O'Connell JX, Fanburg JC, Rosenberg AE . Giant cell tumor of tendon sheath and pigmented villonodular synovitis: immunophenotype suggests a synovial cell origin . Human Pathology . 26 . 7 . 771–5 . July 1995 . 7628850 . 10.1016/0046-8177(95)90226-0.
2. Mackie GC . Pigmented villonodular synovitis and giant cell tumor of the tendon sheath: scintigraphic findings in 10 cases . Clinical Nuclear Medicine . 28 . 11 . 881–5 . November 2003 . 14578700 . 10.1097/01.rlu.0000093083.77866.5c .
3. Maheshwari AV, Muro-Cacho CA, Pitcher JD . Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of literature . Knee . 14 . 5 . 402–7 . October 2007 . 17669658 . 10.1016/j.knee.2007.06.004 .
4. Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA . Pigmented villonodular synovitis: radiologic-pathologic correlation . Radiographics . 28 . 5 . 1493–518 . 2008 . 18794322 . 10.1148/rg.285085134 .