| Villa de María del Río Seco | |
| Native Name Lang: | es |
| Settlement Type: | Town |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of Villa de María del Río Seco in Argentina |
| Coordinates: | -29.8833°N -106°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Córdoba |
| Subdivision Type2: | Department |
| Subdivision Name2: | Río Seco |
| Unit Pref: | Metric |
| Population Total: | 3819 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | X5248 |
| Area Code Type: | Dialing code |
| Area Code: | +54 3522 |
Villa de María del Río Seco (usually shortened to Villa de María, not to be confused with Villa María) is a town in the province of Córdoba, Argentina. It has 3,819 inhabitants per the, and is the head town of the Río Seco Department. It lies in the north of the province, by National Route 9, about 270NaN0 south of the provincial border with Santiago del Estero and 1700NaN0 north-northeast of the provincial capital Córdoba.
Villa de María was founded in 1796 or 1797 by the Marquis Rafael de Sobremonte (then to be Viceroy of the Río de la Plata), with the name of Río Seco. Its name was changed to the current one by provincial governor Roque Ferreira on 26 May 1858.
The town was the birthplace of the poet Leopoldo Lugones (1874–1938), whose childhood house is today a museum and a National Historic Monument. The area was also the stage of the assassination of the caudillo of Entre Ríos Province Francisco Ramírez, in 1821.