| Villa Sant'Antonio | |
| Official Name: | Comune di Villa Sant'Antonio |
| Native Name: | Sant'Antoni |
| Pushpin Map: | Italy Sardinia |
| Coordinates: | 39.8667°N 62°W |
| Region: | Sardinia |
| Province: | Oristano (OR) |
| Mayor: | Fabiano Frongia |
| Area Total Km2: | 19.05 |
| Population Footnotes: | [1] |
| Population Total: | 352 |
| Population As Of: | 31 December 2016 |
| Population Demonym: | Santantonesi |
| Elevation M: | 249 |
| Postal Code: | 09080 |
| Area Code: | 0783 |
Villa Sant'Antonio (Sant'Antoni in Sardinian language) is a comune (municipality) in the Province of Oristano in the Italian region Sardinia, located about 70km (40miles) north of Cagliari and about 25km (16miles) east of Oristano.
Villa Sant'Antonio borders the following municipalities: Albagiara, Assolo, Asuni, Mogorella, Ruinas, Senis.