| Official Name: | Vila Guilherme |
| Mapsize: | 250px |
| Image Map1: | Shopping Center Norte 01.jpg |
| Map Caption1: | Center Norte Mall |
| Subdivision Type: | Country |
| Subdivision Name: | Brazil |
| Subdivision Type1: | State |
| Subdivision Name1: | São Paulo |
| Subdivision Type2: | City |
| Subdivision Name2: | São Paulo |
| Government Type: | Subprefecture |
| Leader Title: | Subprefect |
| Leader Name: | Antônio de Pádua Perosa |
| Population As Of: | 2000 |
| Population Total: | 49.984 |
| Blank Name: | HDI |
| Blank Info: | 0.868 –high |
| Website: | Subprefecture of Vila Maria |
Vila Guilherme is a district located in the north of São Paulo.