Vibrio cholerae ToxT activated RNAs explained

In molecular biology, Vibrio cholerae ToxT activated RNAs are small RNAs which are produced by the bacterium Vibrio cholerae. They are regulated by the transcriptional activator ToxT and may play a role in V. cholerae virulence.^[1] Two ToxT activated RNAs have been described: TarA (ToxT activated RNA A) and TarB (ToxT activated RNA B).

TarA

The TarA small RNA regulates PtsG, a glucose transporter involved in the regulation of glucose uptake. Regulation of PtsG by TarA may be dependent upon the Hfq protein, an RNA chaperone.^[2]

TarB

TarB inhibits the expression of Toxin coregulated pilus biosynthesis protein F (TcpF). It does not act in conjunction with Hfq.^[3]

See also

• Vibrio regulatory RNA of OmpA
• Qrr RNA

Notes and References

1. Bardill JP, Hammer BK . Non-coding sRNAs regulate virulence in the bacterial pathogen Vibrio cholerae.. RNA Biology. April 2012. 9. 4. 392–401. 22546941. 10.4161/rna.19975. 3384565.
2. Richard AL, Withey JH, Beyhan S, Yildiz F, DiRita VJ . The Vibrio cholerae virulence regulatory cascade controls glucose uptake through activation of TarA, a small regulatory RNA.. Molecular Microbiology. December 2010. 78. 5. 1171–1181. 21091503. 10.1111/j.1365-2958.2010.07397.x . 3064952.
3. Bradley ES, Bodi K, Ismail AM, Camilli A . A genome-wide approach to discovery of small RNAs involved in regulation of virulence in Vibrio cholerae.. PLOS Pathogens. July 2011. 7. 7. e1002126. 21779167. 10.1371/journal.ppat.1002126 . 3136459 . free .