Vesiculobullous disease explained

A vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon which definition is used). In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous^[1] is sometimes used. Examples of vesiculobullous diseases include:

• Infectious: (viral)
  • Herpes simplex
  • Varicella-Zoster infection
  • Hand, foot and mouth disease
  • Herpangina
  • Measles (Rubeola)
• Immunobullous:
  • Pemphigus vulgaris^[2]
  • Pemphigoid
  • Dermatitis herpetiformishttps://books.google.com/books?id=N0ng2f1hxn4C&dq=Dermatitis+herpetiformis+is+a+vesiculobullous+disease&pg=PA161
  • Linear immunoglobulin-A disease (linear IgA disease)
• Genetic:
  • Epidermolysis bullosa^[3]

Some features are as follows:

Name	Acantholysis?	Ig
epidermolysis bullosa	yes	mostly IgG
bullous pemphigoid	no	mostly IgG
dermatitis herpetiformis	no	IgA

Notes and References

1. Magro . C. M. . Roberts-Barnes . J. . Crowson . A. N. . 10.1016/j.det.2012.06.008 . Direct Immunofluorescence Testing in the Diagnosis of Immunobullous Disease, Collagen Vascular Disease, and Vascular Injury Syndromes . Dermatologic Clinics . 30 . 4 . 763–798, viii . 2012 . 23021058 .
2. Williams DM. Vesiculobullous mucocutaneous disease: pemphigus vulgaris. Journal of Oral Pathology and Medicine. 2695619. 18. 10. December 1989. 544–53. 10.1111/j.1600-0714.1989.tb01551.x.
3. Rao R, Prabhu SS, Sripathi H, Gupta S . Vesiculobullous lesions in lipoid proteinosis: a case report . Dermatol. Online J. . 14 . 7 . 16 . 2008 . 10.5070/D33FQ584H1 . 18718200 .