Vesicular transport protein explained

A vesicular transport protein, or vesicular transporter, is a membrane protein that regulates or facilitates the movement of specific molecules across a vesicle's membrane. As a result, vesicular transporters govern the concentration of molecules within a vesicle.

Types

Examples include:

• Archain
• ARFs
• Clathrin
• Caveolin
• Dynamin and related proteins, such as the EHD protein family
• Rab proteins
• SNAREs
• Vesicular transport adaptor proteins e.g. Sorting nexins
• Synaptotagmin
• TRAPP complex
• Synaptophysin
• Auxilin

Pathways

There are multiple pathways, each using its own coat and GTPase.^[1]

• COP 1 (Cytosolic coat protein complex) : retrograde transport; Golgi ----> Endoplasmic reticulum
• COP 2 (Cytosolic coat protein complex) : anterograde transport; RER -----> cis-Golgi
• Clathrin : trans-Golgi ----> Lysosomes, Plasma membrane ----> Endosomes (receptor-mediated endocytosis)

See also

• Membrane transport protein

Notes and References

1. Book: Yasushi Sako. Cell Signaling Reactions: Single-Molecular Kinetic Analysis. 15 December 2010. 1 October 2010. Springer. 978-90-481-9863-4. 168–.