Vesicular glutamate transporter 3 explained

Vesicular glutamate transporter 3 (VGLUT3) is a protein that in humans is encoded by the SLC17A8 gene.^[1]

Function

This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft.^[1]

Clinical significance

Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness type 25 (DFNA25).^[2]

Further reading

• Greene CC, McMillan PM, Barker SE, etal . DFNA25, a novel locus for dominant nonsyndromic hereditary hearing impairment, maps to 12q21-24. . Am. J. Hum. Genet. . 68 . 1 . 254–60 . 2001 . 11115382 . 10.1086/316925 . 1234922.
• Fremeau RT . Voglmaier S . Seal RP . Edwards RH . VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. . Trends Neurosci. . 27 . 2 . 98–103 . 2004 . 15102489 . 10.1016/j.tins.2003.11.005 . 16619295 .
• Book: Seal RP . Edwards RH . Neurotransmitter Transporters . The diverse roles of vesicular glutamate transporter 3 . 175. . 137–50 . 2006 . 16722234 . 10.1007/3-540-29784-7_7 . Handbook of Experimental Pharmacology . 3-540-29783-9 . free .
• Ruel J, Emery S, Nouvian R, etal . Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. . Am. J. Hum. Genet. . 83 . 2 . 278–92 . 2008 . 18674745 . 10.1016/j.ajhg.2008.07.008 . 2495073.
• Almqvist J, Huang Y, Laaksonen A, etal . Docking and homology modeling explain inhibition of the human vesicular glutamate transporters. . Protein Sci. . 16 . 9 . 1819–29 . 2007 . 17660252 . 10.1110/ps.072944707 . 2206968.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Gong J, Jellali A, Mutterer J, etal . Distribution of vesicular glutamate transporters in rat and human retina. . Brain Res. . 1082 . 1 . 73–85 . 2006 . 16516863 . 10.1016/j.brainres.2006.01.111 . 2868346 .
• Linke N . Bódi N . Resch BE . Developmental pattern of three vesicular glutamate transporters in the myenteric plexus of the human fetal small intestine. . Histol. Histopathol. . 23 . 8 . 979–86 . 2008 . 18498073 . etal.
• Takamori S . Malherbe P . Broger C . Jahn R . Molecular cloning and functional characterization of human vesicular glutamate transporter 3. . EMBO Rep. . 3 . 8 . 798–803 . 2002 . 12151341 . 10.1093/embo-reports/kvf159 . 1084213.

Notes and References

1. Web site: Entrez Gene: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter).
2. Ruel J, Emery S, Nouvian R, etal . Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice . Am. J. Hum. Genet. . 83 . 2 . 278–92 . August 2008 . 18674745 . 2495073 . 10.1016/j.ajhg.2008.07.008 .