Vesicular glutamate transporter 1 explained

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.^{[1] [2] [3]}

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.^[3]

See also

• Solute carrier family

Further reading

• Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH . Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. . Science . 289 . 5481 . 957–60 . 2000 . 10938000 . 10.1126/science.289.5481.957 . 2000Sci...289..957B .
• Takamori S, Rhee JS, Rosenmund C, Jahn R . Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. . Nature . 407 . 6801 . 189–94 . 2000 . 11001057 . 10.1038/35025070 . 2000Natur.407..189T . 11858/00-001M-0000-0012-F987-C . 4412622 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Eastwood SL, Harrison PJ . Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. . . 73 . 2–3 . 159–72 . 2005 . 15653259 . 10.1016/j.schres.2004.05.010 . 2335413 .
• Alonso-Nanclares L, De Felipe J . Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex. . Neuroscience . 134 . 1 . 59–68 . 2005 . 15961236 . 10.1016/j.neuroscience.2005.03.038 . 25943855 .
• Vinatier J, Herzog E, Plamont MA, etal . Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis. . J. Neurochem. . 97 . 4 . 1111–25 . 2006 . 16606361 . 10.1111/j.1471-4159.2006.03821.x . 3133505 . free .
• Almqvist J, Huang Y, Laaksonen A, etal . Docking and homology modeling explain inhibition of the human vesicular glutamate transporters. . Protein Sci. . 16 . 9 . 1819–29 . 2007 . 17660252 . 10.1110/ps.072944707 . 2206968.

Notes and References

1. Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM . Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter . J Neurochem . 66 . 6 . 2227–38 . Jul 1996 . 8632143 . 10.1046/j.1471-4159.1996.66062227.x. 23177236 .
2. Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J . Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter . J Neurochem . 74 . 6 . 2622–5 . Jun 2000 . 10820226 . 10.1046/j.1471-4159.2000.0742622.x . 37857748 . free .
3. Web site: Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7.