| Vesc | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Vesc (Drôme).svg |
| Arrondissement: | Nyons |
| Canton: | Dieulefit |
| Insee: | 26373 |
| Postal Code: | 26220 |
| Mayor: | Alain Jeune[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 44.522°N 5.151°W |
| Elevation M: | 655 |
| Elevation Min M: | 477 |
| Elevation Max M: | 1448 |
| Area Km2: | 40.48 |
Vesc (in French pronounced as /vɛsk/) is a commune in the Drôme department in southeastern France.