Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase explained

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Ec Number:	4.2.1.134

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (PHS1 (gene), PAS2 (gene)) is an enzyme with systematic name very-long-chain (3R)-3-hydroxyacyl-CoA hydro-lyase.^{[1] [2]} This enzyme catalyses the following chemical reaction

a very-long-chain (3R)-3-hydroxyacyl-CoA

\rightleftharpoons a very-long-chain trans-2,3-dehydroacyl-CoA + H₂O

This is the third component of the elongase.

Notes and References

1. Bach L, Michaelson LV, Haslam R, Bellec Y, Gissot L, Marion J, Da Costa M, Boutin JP, Miquel M, Tellier F, Domergue F, Markham JE, Beaudoin F, Napier JA, Faure JD . The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development . Proceedings of the National Academy of Sciences of the United States of America . 105 . 38 . 14727–31 . September 2008 . 18799749 . 2567193 . 10.1073/pnas.0805089105 . free .
2. Kihara A, Sakuraba H, Ikeda M, Denpoh A, Igarashi Y . Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation . The Journal of Biological Chemistry . 283 . 17 . 11199–209 . April 2008 . 18272525 . 10.1074/jbc.m708993200 . free .