Vertebrate Genomes Project Explained

The Vertebrate Genomes Project (VGP) is a project which aims to generate high-quality, complete reference genomes of all 66,000 vertebrate species. It is an international cooperation project with members from more than 50 separate institutions and was launched in February 2017.[1] [2] [3] [4] [5]

In October 2021, VGP partnered with Colossal Biosciences to sequence and assemble elephant genomes for preservation purposes.[6]

In April 2022, VGP partnered with the Human Genome Project[7] and the African BioGenome Project for sequencing research.[8]

In July 2022, VGP and Colossal Biosciences announced that they successfully sequenced the entire Asian elephant genome; this is the first time that mammalian genetic code has been fully sequenced to this degree since the Human Genome Project was completed in the early 2000s.[9]

In November 2022, VGP successfully sequenced the Nile Rat genome in order to facilitate research on type 2 diabetes and the health effects of circadian rhythm disruption. Not only did researchers sequence an individual rat, but they also sequenced both its parents, allowing them to separate the original rat’s alleles by parental haplotype. The resulting sequence showed that the vast majority of expected protein-coding genes were accounted for. [10] [11]

External links

Vertebrate Genomes Project

Notes and References

  1. Web site: The Vertebrate Genomes Project at Rockefeller University.
  2. Towards complete and error-free genome assemblies of all vertebrate species. Arang. Rhie. Shane A.. McCarthy. Olivier. Fedrigo. Joana. Damas. Giulio. Formenti. Sergey. Koren. Marcela. Uliano-Silva. William. Chow. Arkarachai. Fungtammasan. Juwan. Kim. Chul. Lee. Byung June. Ko. Mark. Chaisson. Gregory L.. Gedman. Lindsey J.. Cantin. Francoise. Thibaud-Nissen. Leanne. Haggerty. Iliana. Bista. Michelle. Smith. Bettina. Haase. Jacquelyn. Mountcastle. Sylke. Winkler. Sadye. Paez. Jason. Howard. Sonja C.. Vernes. Tanya M.. Lama. Frank. Grutzner. Wesley C.. Warren. Christopher N.. Balakrishnan. Dave. Burt. Julia M.. George. Matthew T.. Biegler. David. Iorns. Andrew. Digby. Daryl. Eason. Bruce. Robertson. Taylor. Edwards. Mark. Wilkinson. George. Turner. Axel. Meyer. Andreas F.. Kautt. Paolo. Franchini. H. William. Detrich. Hannes. Svardal. Maximilian. Wagner. Gavin J. P.. Naylor. Martin. Pippel. Milan. Malinsky. Mark. Mooney. Maria. Simbirsky. Brett T.. Hannigan. Trevor. Pesout. Marlys. Houck. Ann. Misuraca. Sarah B.. Kingan. Richard. Hall. Zev. Kronenberg. Ivan. Sović. Christopher. Dunn. Zemin. Ning. Alex. Hastie. Joyce. Lee. Siddarth. Selvaraj. Richard E.. Green. Nicholas H.. Putnam. Ivo. Gut. Jay. Ghurye. Erik. Garrison. Ying. Sims. Joanna. Collins. Sarah. Pelan. James. Torrance. Alan. Tracey. Jonathan. Wood. Robel E.. Dagnew. Dengfeng. Guan. Sarah E.. London. David F.. Clayton. Claudio V.. Mello. Samantha R.. Friedrich. Peter V.. Lovell. Ekaterina. Osipova. Farooq O.. Al-Ajli. Simona. Secomandi. Heebal. Kim. Constantina. Theofanopoulou. Michael. Hiller. Yang. Zhou. Robert S.. Harris. Kateryna D.. Makova. Paul. Medvedev. Jinna. Hoffman. Patrick. Masterson. Karen. Clark. Fergal. Martin. Kevin. Howe. Paul. Flicek. Brian P.. Walenz. Woori. Kwak. Hiram. Clawson. Mark. Diekhans. Luis. Nassar. Benedict. Paten. Robert H. S.. Kraus. Andrew J.. Crawford. M. Thomas P.. Gilbert. Guojie. Zhang. Byrappa. Venkatesh. Robert W.. Murphy. Klaus-Peter. Koepfli. Beth. Shapiro. Warren E.. Johnson. Federica. Di Palma. Tomas. Marques-Bonet. Emma C.. Teeling. Tandy. Warnow. Jennifer Marshall. Graves. Oliver A.. Ryder. David. Haussler. Stephen J.. O’Brien. Jonas. Korlach. Harris A.. Lewin. Kerstin. Howe. Eugene W.. Myers. Richard. Durbin. Adam M.. Phillippy. Erich D.. Jarvis. 3. April 29, 2021. Nature. 592. 7856. 737–746. 10.1038/s41586-021-03451-0. 33911273 . 8081667 . 2021Natur.592..737R . free.
  3. Web site: Scientists look to map the genes of thousands of animals. AP NEWS. 13 September 2018 .
  4. Web site: Researchers reboot ambitious effort to sequence all vertebrate genomes, but challenges loom. September 13, 2018. Science | AAAS.
  5. Web site: Massive Animal Sequencing Effort Releases First Set of Genomes. The Scientist Magazine®.
  6. News: Colossal Begins Ambitious De-Extinction Plan With Elephant Sequencing Project, Despite Critics. Christie Rizk. October 6, 2021. Genome Web.
  7. Wang. T. Antonacci-Fulton. L . Howe. K. Lawson. H. Lucas. J. Phillippy. A. Popejoy. A. Asri . M. Carson. C. Chaisson. M. Chang. X. Cook-Deegan. R. Felsenfeld . A. Fulton. R. Garrison. E. Garrison. N. Graves-Lindsay. T. Ji . H. Kenny. E. Koenig. B. Li. D. Marschall. T. McMichael . J. Novak. A. Purushotham. D. Schneider. V. Schultz. B. Smith . M. Sofia. H. Weissman. T. Flicek. P. Li. H. Miga. K . Paten. B. Jarvis. E. Hall. I. Eichler. E. Haussler. D. The Human Pangenome Project: a global resource to map genomic diversity. Science. April 20, 2022. 604. 7906. 437–446. 10.1038/s41586-022-04601-8. 35444317. 2022Natur.604..437W. 248297723. free. 9402379.
  8. News: Sequencing 100,000 species to secure food supplies. John Agaba. April 12, 2022. SciDevNet.
  9. News: Colossal Biosciences and the Vertebrate Genomes Project Sequence the Asian Elephant Genome, Chromosome to Chromosome. July 12, 2022. BioSpace.
  10. News: Genome Spotlight: Nile Rat (Avicanthis niloticus). Christie Wilcox. November 23, 2022. The Scientist.
  11. News: Huishi Toh. Chentao Yang. Giulio Formenti. Kalpana Raja. Lily Yan. Alan Tracey. William Chow. Kerstin Howe. Lucie A. Bergeron. Guojie Zhang. Bettina Haase. Jacquelyn Mountcastle. Olivier Fedrigo. John Fogg. Bogdan Kirilenko. Chetan Munegowda. Michael Hiller. Aashish Jain. Daisuke Kihara. Arang Rhie. Adam M. Phillippy. Scott A. Swanson. Peng Jiang. Dennis O. Clegg. Erich D. Jarvis. James A. Thomson. Ron Stewart. Mark J. P. Chaisson. Yury V. Bukhman. November 8, 2022. A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes. BMC Biology. 20 . 10.1186/s12915-022-01427-8 . free .

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