Verkine Karakashian (1856–1933) was an Ottoman-Armenian actress and soprano.
Verkine Karakashian was born in Constantinople, today Istanbul, in 1856. She was the younger sister of actress Yeranuhi Karakashian. She debuted on the stage at Aziziye Theater in Üsküdar, Istanbul in 1869. Firstly, she entered the theater company of Güllü Agop. She later performed as soprano at the operetta company of Serovpe Benliyan. Following her marriage in 1914, she retired from the stage and lived in Symirna, today İzmir. She died in Athens, Greece in 1933.