| Rio Verde Grande | |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Mouth location in Brazil |
| Source1 Location: | Minas Gerais |
| Mouth Coordinates: | -14.5618°N -43.8764°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
Rio Verde Grande (Portuguese for "big green river") is a river of Minas Gerais state in eastern Brazil, that forms the boundary with Bahia state in its lowest reaches.It is a tributary of the São Francisco River.
The Caminho dos Gerais State Park protects the sources of the Verde Pequeno River, a tributary of the Rio Verde Grande, which in turn is a tributary of the São Francisco River.