| Official Name: | Veliki Obrež |
| Pushpin Map: | Slovenia |
| Pushpin Label Position: | left |
| Pushpin Map Caption: | Location in Slovenia |
| Subdivision Type: | Country |
| Subdivision Name: | Slovenia |
| Subdivision Type1: | Traditional region |
| Subdivision Name1: | Styria |
| Subdivision Type2: | Statistical region |
| Subdivision Name2: | Lower Sava |
| Subdivision Type3: | Municipality |
| Subdivision Name3: | Brežice |
| Area Total Km2: | 3.61 |
| Population As Of: | 2020 |
| Population Total: | 290 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | 45.9033°N 15.6684°W |
| Elevation M: | 155.9 |
| Footnotes: | [1] |
Veliki Obrež (in Slovenian pronounced as /ˈʋeːliki ɔˈbɾeːʃ/, German: Großobresch[2]) is a settlement on the right bank of the Sotla River in the Municipality of Brežice in eastern Slovenia, close to the border with Croatia. The area is part of the traditional region of Styria. It is now included with the rest of the municipality in the Lower Sava Statistical Region.[3] The Jovsi wetland lies north of the village.