| Veinticinco de Mayo Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map Caption: | Location of Veinticinco de Mayo Department in Argentina |
| Coordinates: | -26.9167°N -63°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Chaco Province |
| Seat Type: | Head town |
| Seat: | Machagai |
| Unit Pref: | Metric |
| Area Total Km2: | 2,576 |
| Population Total: | 28,070 |
| Population Density Km2: | auto |
| Population Demonym: | Tapenagense |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code: | H3534 |
| Area Code: | 03734 |
Veinticinco de Mayo is a department of Chaco Province in Argentina.
The provincial subdivision has a population of about 28,000 inhabitants in an area of 2,576 km², and its capital city is Machagai, which is located around 1,140 km from the Capital federal.