| Vasile Gafencu | |
| Term Start: | 1917 |
| Term End: | 1918 |
| Birth Date: | 1 February 1886 |
| Birth Place: | Sîngerei |
| Death Place: | Arkhangelsk |
| Party: | National Moldavian Party |
| Children: | Valeriu, Valentina, Eleonora, and Elizabeta |
Vasile Gafencu (1 February 1886 – 16 March 1942) was a Bessarabian politician.
He was the father of Valeriu Gafencu (1921–1952), nicknamed The Saint of Prisons.[1]
He served as Member of the Moldovan Parliament (1917–1918).After the Soviet occupation of Bessarabia and northern Bukovina in 1940, Gafencu was deported to Siberia by the Soviet authorities.