Valofane Explained

Valofane is a sedative drug structurally related to the barbiturates[1] and similar drugs such as primidone. It is metabolized once inside the body to form the barbiturate proxibarbital (proxibarbal) and is thus a prodrug.[2]

Notes and References

  1. Traversa U, Puppini P, Jacquot C, Vertua R . Effect of an atypical barbiturate, the 2-allophanyl-2-allyl-4-valerolactone (valofan), on exploratory behaviour and brain serotonin concentrations in mice . Journal de Pharmacologie . 16 . 3 . 279–90 . 1985 . 2415778 .
  2. Lambrey B, Compagnon PL, Jacquot C . Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats . European Journal of Drug Metabolism and Pharmacokinetics . 6 . 3 . 161–9 . 1981 . 6118275 . 10.1007/BF03189485 . 10197120 .

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