Valine—tRNA ligase explained

Valine—tRNA ligase
Ec Number:	6.1.1.9
Cas Number:	9023-47-6
Go Code:	0004832

In enzymology, a valine—tRNA ligase is an enzyme that catalyzes the chemical reaction

ATP + L-valine + tRNAVal

\rightleftharpoons AMP + diphosphate + L-valyl-tRNAVal

The 3 substrates of this enzyme are ATP, L-valine, and tRNA(Val), whereas its 3 products are AMP, diphosphate, and L-valyl-tRNA(Val).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-valine:tRNAVal ligase (AMP-forming). Other names in common use include valyl-tRNA synthetase, valyl-transfer ribonucleate synthetase, valyl-transfer RNA synthetase, valyl-transfer ribonucleic acid synthetase, valine transfer ribonucleate ligase, and valine translase. This enzyme participates in valine, leucine and isoleucine biosynthesis and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes,,,, and .

See also

• VARS

References

• Berg P, Bergmann FH, Ofengand EJ, Dieckmann M . 1961 . The enzymic synthesis of amino acyl derivatives of ribonucleic acid I. The mechanism of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid formation . J. Biol. Chem. . 236 . 1726 - 1734 .
• Bergmann FH, Berg P, Dieckmann M . 1961 . The enzymic synthesis of amino acyl derivatives of ribonucleic acid II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli . J. Biol. Chem. . 236 . 1735 - 1740 .