Valienamine Explained
Valienamine is a C-7 aminocyclitol found as a substructure of pseudooligosaccharides such as the antidiabetic drug acarbose[1] and the antibiotic validamycin. It can be found in Actinoplanes species.[2]
It is an intermediate formed by microbial degradation of validamycins.
External links
Notes and References
- Laube. Heiner. Acarbose An Update of Its Therapeutic Use in Diabetes Treatment. Clinical Drug Investigation. March 2002. 22. 3. 141–156. 10.2165/00044011-200222030-00001.
- Zhang CS, Stratmann A, Block O, etal . Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway . J. Biol. Chem. . 277 . 25 . 22853–62 . June 2002 . 11937512 . 10.1074/jbc.M202375200 . free .
