Vaginal anomalies explained

Vaginal anomalies are abnormal structures that are formed (or not formed) during the prenatal development of the female reproductive system and are rare congenital defects that result in an abnormal or absent vagina.[1]

When present, they are often found with uterine, skeletal and urinary abnormalities.[2] [3] This is because these structures, like the vagina, are most susceptible to disruption during crucial times of organ-genesis. Many of these defects are classified under the broader term Müllerian duct anomalies.[2] [4] Müllerian duct anomalies are caused by a disturbance during the embryonic time of genitourinary development.[5]

The other isolated incidents of vaginal anomalies can occur with no apparent cause. Oftentimes vaginal anomalies are part of a cluster of defects or syndromes. In addition, inheritance can play a part as can prenatal exposure to some teratogens.[6] [7] [8] Many vaginal anomalies are not detected at birth because the external genitalia appear to be normal. Other organs of the reproductive system may not be affected by an abnormality of the vagina. The uterus, fallopian tubes and ovaries can be functional despite the presence of a defect of the vagina and external genitalia.[2]

A vaginal anomaly may not affect fertility. Though it depends on the extent of the vaginal defect, it is possible for conception to occur. In instances where a functional ovary exists, IVF may be successful. Functioning ovaries in a woman with a vaginal defect allows the implantation of a fertilized ovum into the uterus of an unaffected gestational carrier, usually another human. A successful conception and can occur.[9] Vaginal length varies from 6.5 to 12.5 cm. Since this is slightly shorter than older descriptions, it may impact the diagnosis of women with vaginal agenesis or hypoplasia who may unnecessarily be encouraged to undergo treatment to increase the size of the vagina.[10]

Vaginal anomalies may cause difficulties in urination, conception, pregnancy, impair sex. Psychosocial effects can also exist.[11]

Signs and symptoms

Isolated anomalies

Some anomalies are found upon examination shortly after birth or when the development of sexual characteristics does not progress as expected. Defects that prevent menstrual flow become obvious when amenorrhea occurs.

Syndromes

Syndromes may take longer to identify since they are rare and often involve errors in metabolism. Many syndromes share the same signs and symptoms.

Associated uterine defects

Uterine defects can accompany vaginal abnormalities:

Women with uterine abnormalities may have associated renal abnormalities including unilateral renal agenesis.[12]

Anomalies associated with syndromes

Some congenital syndromes present with vaginal anomalies in association with other serious conditions. These include Fraser syndrome, WNT4 deficiency, and Bardet-Biedl syndrome,[13] Isolated incidents of vaginal anomalies can occur with no apparent cause and in other instances these anomalies are part of a syndrome or cluster of other abnormalities. The origin of many vaginal anomalies is due to a disturbance during the embryonic stage of genitourinary development. Inheritance can play a part as can prenatal exposure to hormones and teratogens.[7] Though the presence of a vaginal anomaly does not necessarily prevent conception and a successful pregnancy when a functional uterus and ovaries are present, vaginal anomalies increase the risk of miscarriage.

!Syndrome!Acronyms!References
Fraser syndrome[14] [15] [16] [17] [18] [19]
WNT4 deficiency[20]
Bardet–Biedl syndrome[21]
McKusick–Kaufman syndrome[22]
Herlyn–Werner–Wunderlich syndromeHWW, OHVIRA[23] [24] [25] [26]
Congenital adrenal hyperplasia
Mullerian anomalies
Müllerian agenesis[27] [28]
Congenital adrenal hyperplasia
OEIS complex[29]
Exstrophy–epispadias complex[30]
Prenatal exposure to some hormones can cause vaginal anomalies as can the lack of necessary hormones needed for normal development.[31] Diethylstilbestrol (DES), also known formerly (and inappropriately) as stilboestrol, is a synthetic nonsteroidal estrogen and teratogen that can cause vaginal abnormalities in the developing embryo.

Cause

The cause of isolated cases of vaginal anomalies can not always be identified, though disruption of the embryonic development of the vagina likely plays a significant role.

Diagnosis

Imaging studies are usually the most useful in diagnosing vaginal anomalies including retrograde contrast studies. An anomaly scan can be helpful, especially detecting the presence of a urogenital syndrome. Genetic and metabolic defects require further testing to support a diagnosis.

Treatment

Vaginal anomalies are treated surgically.[32] A 'neo-vagina' can be constructed for those girls and women who do not have a vagina.[33] [34] Vaginal septa are treated surgically.[35] [36]

The most common vaginal anomaly is an imperforate hymen. This anomaly occurs often enough that it can be detected by some pediatricians shortly after birth. It can be corrected through a minor surgery and may be delayed until puberty.[37] The hymen can be unusually thick or partially obstructed by the presence of fibrous bands of tissue. An imperforate hymen can also present with other abnormalities such as septa. An imperforate hymen can be displaced and its location may not be where it is expected. Other abnormalities of the hymen can exist including the presence of septa, displacement and a hymen that consists of microperforations.[38] [39] Uncommonly, a double hymen is present.[40] [41] [42] The imperforate hymen is treated by excision and drainage. Sometimes a small border of hymenal tissue is left around the opening of the vagina.[43]

Congenital adrenal hyperplasia can cause the abnormal development of the vagina.[44] [45] [46] Vaginal adenosis is the abnormal presence of cervical and uterine tissue within the wall of the vagina.[47] Ten percent of women have this condition and remain unsymptomatic. It rarely develops into a malignancy.[48] Cloacal exstrophy is a condition when two vaginas are present.[49] [50] [51] Vaginal agenesis or the complete absence of the vagina affects 1 out of 5,000 women.[52] A hemivagina is the abnormal presence of a partial vagina that is attached to the wall of the functioning vagina. The hemivagina does not open to the normal vagina and is attached to an abnormal, second uterus.[53] Vaginal hypoplasia is the under-development of the vagina and is found in instances of complete androgen insensitivity syndrome.[54] Vaginal septa are structures consisting of fibrous tissue that block the vagina.[55] The tissue extends horizontally, blocking or partially blocking the vaginal canal or transversely essentially creating two vaginas that connect to a normal uterus.[56] [57] Septa can prevent menstrual flow and result in painful intercourse, though some women do not have symptoms.[58] Many vaginal anomalies are not detected at birth because the external genitalia can appear to be normal.

Notes and synonyms!Treatment!References
Imperforate hymen1 in 1000-2000Mucometrocolpos and Hematocolpos are complicationssurgical[59] [60]
Vaginal adenosis1 in tenoften without symptomsnone[61]
Cloacal exstrophy3.3 in 100,000syn: Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS)surgical[62] [63] [64] [65]
Vaginal agenesis1 in 5000surgical and ongoing[66]
Hemivaginahemivagina does not open to the normal vagina and is attached to an abnormal, second uterus, also occurs in the syndrome Uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis (OHVIRA)[67]
Vaginal hypoplasia
Vaginal atresia
Congenital vaginal fistulasurgical[68] [69]
Septa1 in 70,000Septa can prevent menstrual flow and result in painful intercourse; others have no symptoms; Transverse septa often present with kidney defects.surgical or none[70] [71] [72]
Persistent cloaca[73]
Urogenital sinusurinary system and vagina open into a common channel[74] [75]

Epidemiology

The occurrence of vaginal defects varies widely and some are only known from case studies. The prevalence of an imperforate hymen is 1 in 1000.

History

Notable is the mention of vaginal anomalies and pelvic organ prolapse in older cultures and locations. In 1500 B.C. Egyptians wrote about the "falling of the womb". In 400 B.C. a Greek physician documented his observations and treatments:

"After the patient had been tied to a ladder-like frame, she was tipped upward so that her head was toward the bottom of the frame. The frame was then moved upward and downward more or less rapidly for approximately 3–5 min. As the patient was in an inverted position, it was thought that the prolapsing organs of the genital tract would be returned to their normal position by the force of gravity and the shaking motion."[76]

Hippocrates also described the prolapse of other organs out through the vagina. In 1521, Berengario da Carpi performed the first surgical treatment for prolapse. This was to tie a rope around the prolapse, tighten it for two days until it was no longer viable and cut it off. Wine, aloe, and honey were then applied to the stump.

References regarding the existence of vaginal anomalies related to müllerian defects have been traced back to 300 BC when a historian described a case of vaginal agenesis.[77]

In 1823, other physicians proposed that vaginoplasty may provide treatment for pelvic organ prolapse. In 1830, the first dissection of the vagina was performed on a living woman. Other vaginal repairs were described in 1834 and treatment sometimes the suturing the edges of a vaginal defect. In 1859 a solution to vaginal elongation was to remove the cervix. In 1866, methods that resembled those used today came into practice. Surgery on the anterior vaginal wall at this time did not have to involve full-thickness repairs to be successful. Sim subsequently developed another procedure that did not require the full-thickness dissection of the vaginal wall. Shortly after this time it was proposed that reattaching the vagina to support structures was more successful and resulted in less recurrence. This same proposal was proposed again in 1976 but further studies indicated that the recurrence rate was not better. Further advances in 1961 began when surgeons started to reattach of the anterior vaginal wall to Cooper's ligament.

In 1955, surgical mesh began to be used to strengthen pelvic tissue. In 1970, tissue from pigs began to be used to strengthen the anterior vaginal wall in surgery. Beginning in 1976, improvement in suturing began along with the surgical removal of the vagina being used to treat prolapse of the bladder. In 1991, assumptions about the detailed anatomy of the pelvic support structures began to be questioned regarding the existence of some pelvic structures and the non-existence of others. More recently, the use of stem cells, robot-assisted laparoscopic surgery are being used during vaginectomy and vaginoplasty.

See also

External links

Notes and References

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  2. 2016-06-01. Mullerian Duct Anomalies: Overview, Incidence and Prevalence, Embryology.
  3. News: Vaginal Anomalies - Pediatrics - Merck Manuals Professional Edition. Merck Manuals Professional Edition. 2018-01-06. en-US.
  4. Web site: Vaginal Anomalies-Pediatrics-Merck Manuals Professional Edition. 2018-01-06.
  5. Mullerian Duct Anomalies: Overview, Incidence and Prevalence, Embryology. 2016-06-01.
  6. The most notable teratogen that is strongly associated with vaginal anomalies is the synthetic hormone Diethylstilbestrol
  7. The inheritance patterns of some vaginal anomalies can be autosomal dominant, autosomal recessive, and X-linked disorders.
  8. 2017-05-04. Imperforate Hymen: Background, Problem, Epidemiology.
  9. Altchek A, Paciuc J . Successful pregnancy following surgery in the obstructed uterus in a uterus didelphys with unilateral distal vaginal agenesis and ipsilateral renal agenesis: case report and literature review . Journal of Pediatric and Adolescent Gynecology . 22 . 5 . e159-62 . October 2009 . 19576808 . 10.1016/j.jpag.2009.02.001 .
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  11. News: Overview of Congenital Genitourinary Anomalies - Pediatrics - Merck Manuals Professional Edition. Merck Manuals Professional Edition. 2018-02-06. en-US.
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