Microbicide Trials Network Explained

The Microbicide Trials Network (MTN, 2006-2021) was a United States government-funded research organization working in the field of microbicides for sexually transmitted diseases.^{[1] [2]} The MTN focused on research into microbicides which would prevent HIV infection. The MTN was a member of HANC. After its closure, partner organization HIV Prevention Trials Network took control of its projects.^[2]

Research

The MTN's notable research included various clinical trials.

The results of the CAPRISA 004 trial inspired the research of the MTN and the microbicide field.^[3]

The Vaginal and Oral Interventions to Control the Epidemic (VOICE) found a vaginal gel containing an anti-HIV drug to be ineffective at preventing HIV transmission..^[4]

The HOPE study tested dapivirine vaginal rings for HIV prevention in 1,456 study participants at 14 sites in Malawi, South Africa, Uganda and Zimbabwe.^[5]

Notes and References

1. Web site: Hillier . Sharon . Thank you for these past 15 years . www.mtnstopshiv.org . Microbicide Trials Network . 30 November 2021.
2. Web site: Buhl . Larry . NIH Restructures HIV Clinical Trial Networks; AIDS Director Touts Milestones . thebodypro.com . . 4 January 2021.
3. Web site: Alcorn . Keith . Tenofovir-based microbicide gel reduces risk of infection for women by 39% . aidsmap.com . . en . 19 July 2010.
4. Web site: Baffling Failure of Vaginal Gel Laced With Anti-HIV Drug - ScienceNOW . Jon . Cohen . news.sciencemag.org . 28 November 2011 . 6 March 2012 . dead . https://web.archive.org/web/20120206005045/http://news.sciencemag.org/sciencenow/2011/11/baffling-failure-of-vaginal-gel-.html . 6 February 2012 .
5. Web site: Most women use vaginal ring for HIV prevention in open-label study . National Institutes of Health (NIH) . EN . 23 July 2019.