| Official Name: | Vadillo de la Guareña |
| Settlement Type: | Municipality |
| Image Caption: | Town square. |
| Pushpin Map: | Spain |
| Pushpin Map Caption: | Spain |
| Subdivision Name3: | La Guareña |
| Leader Title: | Mayor |
| Leader Name: | Fernando Javier Ruíz Martín |
| Area Total Km2: | 44 |
| Elevation M: | 713 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
| Coordinates: | 41.2819°N -5.3528°W |
Vadillo de la Guareña is a municipality located in the province of Zamora, Castile and León, Spain.