VSIG1 explained

V-set and immunoglobulin domain containing 1 is a protein that in humans is encoded by the VSIG1 gene.^[1]

Function

This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in a normal stomach and testis, as well as in gastric, esophageal, and ovarian cancers. Alternatively spliced transcript variants, encoding different isoforms, have been found for this gene. [provided by RefSeq, Dec 2009].

Further reading

• Scanlan MJ, Ritter G, Yin BW, Williams C, Cohen LS, Coplan KA, Fortunato SR, Frosina D, Lee SY, Murray AE, Chua R, Filonenko VV, Sato E, Old LJ, Jungbluth AA . Glycoprotein A34, a novel target for antibody-based cancer immunotherapy . Cancer Immun. . 6 . 2 . January 2006 . 16405301 .
• Chen Y, Pan K, Li S, Xia J, Wang W, Chen J, Zhao J, Lü L, Wang D, Pan Q, Wang Q, Li Y, He J, Li Q . Decreased expression of V-set and immunoglobulin domain containing 1 (VSIG1) is associated with poor prognosis in primary gastric cancer . J Surg Oncol . 106 . 3 . 286–93 . September 2012 . 22095633 . 10.1002/jso.22150 . 2027.42/92382 . 12675519 . free .

Notes and References

1. Web site: Entrez Gene: V-set and immunoglobulin domain containing 1. 2018-09-09.