VPS39 explained

hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.^{[1] [2]}

This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.

Further reading

• Nakajima D . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . vanc. Okazaki N . Yamakawa H . 3 . Kikuno . R . Ohara . O . Nagase . T . free .
• Nagase T . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 5 . 277–286 . 1999 . 9872452 . 10.1093/dnares/5.5.277 . vanc. Ishikawa K . Suyama M . 3 . Kikuno . R . Miyajima . N . Tanaka . A . Kotani . H . Nomura . N . Ohara . O . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–1795 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–435 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . vanc. Weil B . Wellenreuther R . 3 . Gassenhuber . J . Glassl . S . Ansorge . W . Böcher . M . Blöcker . H . Bauersachs . S .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Felici A . TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling . EMBO J. . 22 . 17 . 4465–4477 . 2003 . 12941698 . 10.1093/emboj/cdg428 . 202370 . vanc. Wurthner JU . Parks WT . 3 . Giam . LR . Reiss . M . Karpova . TS . McNally . JG . Roberts . AB .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wiemann S . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–2144 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . vanc. Arlt D . Huber W . 3 . Wellenreuther . R . Schleeger . S . Mehrle . A . Bechtel . S . Sauermann . M . Korf . U .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Mehrle A . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–D418 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . vanc. Rosenfelder H . Schupp I . 3 . Del Val . C . Arlt . D . Hahne . F . Bechtel . S . Simpson . J . Hofmann . O .

Notes and References

1. Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS . Human Vam6p promotes lysosome clustering and fusion in vivo . J Cell Biol . 154 . 1 . 109–122 . Jul 2001 . 11448994 . 2196876 . 10.1083/jcb.200102142 .
2. Web site: Entrez Gene: VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae).