VPS33B explained

Vacuolar protein sorting-associated protein 33B is a protein that in humans is encoded by the VPS33B gene.^{[1] [2]}

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.^[2]

Further reading

• Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M . Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b . Cytogenetics and Cell Genetics . 89 . 1–2 . 92–5 . 2000 . 10894945 . 10.1159/000015571 . 38825448 .
• Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H . Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33 . Gene . 264 . 2 . 241–7 . Feb 2001 . 11250079 . 10.1016/S0378-1119(01)00333-X .
• Gissen P, Johnson CA, Morgan NV, Stapelbroek JM, Forshew T, Cooper WN, McKiernan PJ, Klomp LW, Morris AA, Wraith JE, McClean P, Lynch SA, Thompson RJ, Lo B, Quarrell OW, Di Rocco M, Trembath RC, Mandel H, Wali S, Karet FE, Knisely AS, Houwen RH, Kelly DA, Maher ER . Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome . Nature Genetics . 36 . 4 . 400–4 . Apr 2004 . 15052268 . 10.1038/ng1325 . free .
• Gissen P, Johnson CA, Gentle D, Hurst LD, Doherty AJ, O'Kane CJ, Kelly DA, Maher ER . Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights . Human Molecular Genetics . 14 . 10 . 1261–70 . May 2005 . 15790593 . 10.1093/hmg/ddi137 . free .
• Lo B, Li L, Gissen P, Christensen H, McKiernan PJ, Ye C, Abdelhaleem M, Hayes JA, Williams MD, Chitayat D, Kahr WH . Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis . Blood . 106 . 13 . 4159–66 . Dec 2005 . 16123220 . 10.1182/blood-2005-04-1356 . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .

Notes and References

1. Pevsner J, Hsu SC, Hyde PS, Scheller RH . Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking . Gene . 183 . 1–2 . 7–14 . Dec 1996 . 8996080 . 10.1016/S0378-1119(96)00367-8 . free .
2. Web site: Entrez Gene: VPS33B vacuolar protein sorting 33 homolog B (yeast).