VPS24 explained

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.^{[1] [2] [3]}

Function

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.

Interactions

VPS24 has been shown to interact with IGFBP7.

Further reading

• Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
• Babst M, Katzmann DJ, Estepa-Sabal EJ, Meerloo T, Emr SD . Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting . Dev. Cell . 3 . 2 . 271–82 . 2002 . 12194857 . 10.1016/S1534-5807(02)00220-4 . free .
• Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ, Fisher PB . Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization . J. Neurovirol. . 9 . 3 . 372–89 . 2003 . 12775420 . 10.1080/13550280390201263 . 12205568 .
• Strack B, Calistri A, Craig S, Popova E, Göttlinger HG . AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding . Cell . 114 . 6 . 689–99 . 2003 . 14505569 . 10.1016/S0092-8674(03)00653-6 . 10733770 . free .
• von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI . The protein network of HIV budding . Cell . 114 . 6 . 701–13 . 2003 . 14505570 . 10.1016/S0092-8674(03)00714-1 . 16894972 . free .
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD, Yaravoy A . Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins . Proc. Natl. Acad. Sci. U.S.A. . 100 . 21 . 12414–9 . 2003 . 14519844 . 218772 . 10.1073/pnas.2133846100 . 2003PNAS..10012414M . free .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Lin Y, Kimpler LA, Naismith TV, Lauer JM, Hanson PI . Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1 . J. Biol. Chem. . 280 . 13 . 12799–809 . 2005 . 15632132 . 10.1074/jbc.M413968200 . free .
• Yan Q, Hunt PR, Frelin L, Vida TA, Pevsner J, Bean AJ . mVps24p functions in EGF receptor sorting/trafficking from the early endosome . Exp. Cell Res. . 304 . 1 . 265–73 . 2005 . 15707591 . 10.1016/j.yexcr.2004.11.003 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Walker GE, Antoniono RJ, Ross HJ, Paisley TE, Oh Y . Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1 . Oncogene . 25 . 13 . 1943–54 . 2006 . 16302002 . 10.1038/sj.onc.1209213 . free .
• Bache KG, Stuffers S, Malerød L, Slagsvold T, Raiborg C, Lechardeur D, Wälchli S, Lukacs GL, Brech A, Stenmark H . The ESCRT-III Subunit hVps24 Is Required for Degradation but Not Silencing of the Epidermal Growth Factor Receptor . Mol. Biol. Cell . 17 . 6 . 2513–23 . 2006 . 16554368 . 1474783 . 10.1091/mbc.E05-10-0915 .
• Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM . A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex . Genomics . 88 . 3 . 333–46 . 2006 . 16730941 . 10.1016/j.ygeno.2006.04.003 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Zamborlini A, Usami Y, Radoshitzky SR, Popova E, Palu G, Göttlinger H . Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding . Proc. Natl. Acad. Sci. U.S.A. . 103 . 50 . 19140–5 . 2007 . 17146056 . 1748189 . 10.1073/pnas.0603788103 . free .

Notes and References

1. Wilson EM, Oh Y, Hwa V, Rosenfeld RG . Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells . J Clin Endocrinol Metab . 86 . 9 . 4504–11 . Sep 2001 . 11549700 . 10.1210/jcem.86.9.7845 . free .
2. Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD . Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization . J Biol Chem . 278 . 40 . 38786–95 . Sep 2003 . 12878588 . 10.1074/jbc.M306864200 . free .
3. Web site: Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae).