VPS11 explained

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.^[1]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.^[1]

Interactions

VPS11 has been shown to interact with VPS18,^[2] VPS33A^[2] and STX7.^[2]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H . Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33. . Gene . 264 . 2 . 241–7 . 2001 . 11250079 . 10.1016/S0378-1119(01)00333-X .
• Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C . Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. . J. Biol. Chem. . 276 . 31 . 29393–402 . 2001 . 11382755 . 10.1074/jbc.M101778200 . free .
• Kim BY, Ueda M, Kominami E, Akagawa K, Kohsaka S, Akazawa C . Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. . Biochem. Biophys. Res. Commun. . 311 . 3 . 577–82 . 2004 . 14623309 . 10.1016/j.bbrc.2003.10.030 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J . Large-scale cDNA transfection screening for genes related to cancer development and progression. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 524842 . 10.1073/pnas.0404089101 . 2004PNAS..10115724W . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Web site: Entrez Gene: VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae).
2. Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C . Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7 . J. Biol. Chem. . 276 . 31 . 29393–402 . August 2001 . 11382755 . 10.1074/jbc.M101778200 . free .