VPRBP explained

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.^{[1] [2] [3]}

Interactions

VPRBP has been shown to interact with Merlin.^[4]

Further reading

• Tan L, Ehrlich E, Yu XF . DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest . Journal of Virology . 81 . 19 . 10822–30 . October 2007 . 17626091 . 2045451 . 10.1128/JVI.01380-07 .
• Wen X, Duus KM, Friedrich TD, de Noronha CM . The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor . The Journal of Biological Chemistry . 282 . 37 . 27046–57 . September 2007 . 17620334 . 10.1074/jbc.M703955200 . free .
• Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J . Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle . Proceedings of the National Academy of Sciences of the United States of America . 104 . 28 . 11778–83 . July 2007 . 17609381 . 1906728 . 10.1073/pnas.0702102104 . 2007PNAS..10411778H . free .
• Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain JC, Transy C, Margottin-Goguet F . HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase . Cell Cycle . 6 . 2 . 182–8 . January 2007 . 17314515 . 10.4161/cc.6.2.3732 . free .
• Borgne-Sanchez A, Dupont S, Langonné A, Baux L, Lecoeur H, Chauvier D, Lassalle M, Déas O, Brière JJ, Brabant M, Roux P, Péchoux C, Briand JP, Hoebeke J, Deniaud A, Brenner C, Rustin P, Edelman L, Rebouillat D, Jacotot E . Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells . Cell Death and Differentiation . 14 . 3 . 422–35 . March 2007 . 16888644 . 10.1038/sj.cdd.4402018 . free .
• Zhao LJ, Zhang S, Chinnadurai G . Sox9 transactivation and testicular expression of a novel human gene, KIAA0800 . Journal of Cellular Biochemistry . 86 . 2 . 277–89 . 2002 . 12111997 . 10.1002/jcb.10214 . 36090208 .
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 5 . 277–86 . October 1998 . 9872452 . 10.1093/dnares/5.5.277 . free .

Notes and References

1. Zhao LJ, Mukherjee S, Narayan O . Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein . The Journal of Biological Chemistry . 269 . 22 . 15577–82 . June 1994 . 10.1016/S0021-9258(17)40719-8 . 8195203 . free .
2. Zhang S, Feng Y, Narayan O, Zhao LJ . Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP . Gene . 263 . 1–2 . 131–40 . January 2001 . 11223251 . 10.1016/S0378-1119(00)00583-7 .
3. Web site: Entrez Gene: VPRBP Vpr (HIV-1) binding protein.
4. Huang J, Chen J . VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation . Oncogene . 27 . 29 . 4056–64 . July 2008 . 18332868 . 10.1038/onc.2008.44 . free .