VNN1 explained

Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene.^{[1] [2]}

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24.

Further reading

• Aurrand-Lions M, Galland F, Bazin H, etal . Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. . Immunity . 5 . 5 . 391–405 . 1997 . 8934567 . 10.1016/S1074-7613(00)80496-3 . free .
• Maras B, Barra D, Dupré S, Pitari G . Is pantetheinase the actual identity of mouse and human vanin-1 proteins? . FEBS Lett. . 461 . 3 . 149–52 . 1999 . 10567687 . 10.1016/S0014-5793(99)01439-8 . 25738323 .
• Martin F, Malergue F, Pitari G, etal . Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. . Immunogenetics . 53 . 4 . 296–306 . 2001 . 11491533 . 10.1007/s002510100327 . 10763223 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Kristiansen TZ, Bunkenborg J, Gronborg M, etal . A proteomic analysis of human bile. . Mol. Cell. Proteomics . 3 . 7 . 715–28 . 2005 . 15084671 . 10.1074/mcp.M400015-MCP200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Liu T, Qian WJ, Gritsenko MA, etal . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 .
• Min-Oo G, Fortin A, Pitari G, etal . Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. . J. Exp. Med. . 204 . 3 . 511–24 . 2007 . 17312006 . 10.1084/jem.20061252 . 2137903 .

Notes and References

1. Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P . Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6 . Genomics . 53 . 2 . 203–13 . Dec 1998 . 9790769 . 10.1006/geno.1998.5481 .
2. Web site: Entrez Gene: VNN1 vanin 1.