VN1R1 explained

Vomeronasal type-1 receptor 1 is a protein that in humans is encoded by the VN1R1 gene.^{[1] [2]}

Function

Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.

Ligands

• Decanal^[3]
• Hedione^[4]
• Iso E Super^[5]

Further reading

• Giorgi D, Friedman C, Trask BJ, Rouquier S . Characterization of nonfunctional V1R-like pheromone receptor sequences in human . Genome Research . 10 . 12 . 1979–85 . December 2000 . 11116092 . 313059 . 10.1101/gr.10.12.1979 .
• Pantages E, Dulac C . A novel family of candidate pheromone receptors in mammals . Neuron . 28 . 3 . 835–45 . December 2000 . 11163270 . 10.1016/S0896-6273(00)00157-4 . 15023062 . free .
• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S . Identification of G protein-coupled receptor genes from the human genome sequence . FEBS Letters . 520 . 1–3 . 97–101 . June 2002 . 12044878 . 10.1016/S0014-5793(02)02775-8 . 7116392 . free .
• Zhang J, Webb DM . Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates . Proceedings of the National Academy of Sciences of the United States of America . 100 . 14 . 8337–41 . July 2003 . 12826614 . 166230 . 10.1073/pnas.1331721100 . 2003PNAS..100.8337Z . free .
• Mitropoulos C, Papachatzopoulou A, Menounos PG, Kolonelou C, Pappa M, Bertolis G, Gerou S, Patrinos GP . Association study of human VN1R1 pheromone receptor gene alleles and gender . Genetic Testing . 11 . 2 . 128–32 . 2007 . 17627382 . 10.1089/gte.2006.0516 .

Notes and References

1. Rodriguez I, Greer CA, Mok MY, Mombaerts P . A putative pheromone receptor gene expressed in human olfactory mucosa . Nature Genetics . 26 . 1 . 18–9 . September 2000 . 10973240 . 10.1038/79124 . 21063460 .
2. Web site: Entrez Gene: VN1R1 vomeronasal 1 receptor 1.
3. Shirokova E, Raguse JD, Meyerhof W, Krautwurst D. The human vomeronasal type-1 receptor family--detection of volatiles and cAMP signaling in HeLa/Olf cells. FASEB J. 2008 May;22(5):1416-25.
4. Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H . The smelling of Hedione results in sex-differentiated human brain activity . NeuroImage . 113 . 365–73 . June 2015 . 25797832 . 10.1016/j.neuroimage.2015.03.029 . 6526522 .
5. Ouyang J, Bae H, Jordi S, Dao QM, Dossenbach S, Dehn S, Lingnau JB, Kanta De C, Kraft P, List B . The Smelling Principle of Vetiver Oil, Unveiled by Chemical Synthesis . Angew Chem Int Ed Engl . 60 . Feb 2021 . 11 . 5666–5672 . 33315304 . 10.1002/anie.202014609 . 7986879 . (reference 30)