| 2010 MTV Video Music Brazil | |
| Date: | September 16, 2010 |
| Location: | Credicard Hall |
| Host: | Marcelo Adnet |
| Network: | MTV Brasil |
| Previous: | 2009 |
| Next: | 2011 |
The 2010 MTV Video Music Brazil, known as VMB 2010 in Brazil, was held on September 16, 2010, hosted by Marcelo Adnet and took place at the Credicard Hall, São Paulo. It awarded the best in Brazilian music, popular culture and internet culture in the year of 2010. The most notable moments in the show were the 5 awards received by pop band Restart, including for Best New Act and Act of the Year, this last sounded by boos from the audience. There was also a live performance by American alternative rock band OK Go, the appearance of electropop duo 3OH!3, Mexican singer Christian Chávez and Paraguayan model Larissa Riquelme, among many Brazilian personalities.
Winners are in bold.
Note: "Gaiola da Cabeçudas" is a humorous musical group formed by comedians and VJs of MTV Brasil, they are Marcelo Adnet, Rafael Queiroga, Paulinho Serra, Rodrigo Capella and Guilherme Santana, also a satire of the Brazilian funk carioca group Gaiola das Popozudas (Cage of Big-Asses), led by Valesca Popozuda, a real singer.