VIS1 explained

VIS1 (viral integration site 1), also known as HIS-1, is a long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of myeloid leukemia. In murine myeloid leukemias, this gene is a common site of viral insertion by the murine ecotropic retrovirus CasBrM^{[1] [2]} It is conserved amongst vertebrates, including human, mice, cats, pigs, cattle and dogs.^[3] Expression of VIS1 is restricted to epithelial cells, leukemias and carcinomas.^[4]

See also

• Long noncoding RNA

Notes and References

1. Askew DS, Bartholomew C, Buchberg AM, etal . His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia . Oncogene . 6 . 11 . 2041–2047 . November 1991 . 1682866 .
2. Askew DS, Li J, Ihle JN . Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame . Mol. Cell. Biol. . 14 . 3 . 1743–1751 . March 1994 . 8114708 . 358532 . 10.1128/MCB.14.3.1743.
3. Li J, Rhodes JC, Askew DS . Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene . Gene . 184 . 2 . 169–176 . January 1997 . 9031624 . 10.1016/S0378-1119(96)00591-4.
4. Li J, Witte DP, Van Dyke T, Askew DS . Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues . Am. J. Pathol. . 150 . 4 . 1297–1305 . April 1997 . 9094986 . 1858164 .