VEL-101 explained

VEL-101, formerly FR104, is an experimental monovalent, pegylated fab' antibody against CD28. It is developed for transplant rejection and autoimmune diseases.^{[1] [2] [3] [4] [5]}

Notes and References

1. Ville . Simon . Poirier . Nicolas . Branchereau . Julien . Charpy . Vianney . Pengam . Sabrina . Nerriere-Daguin . Véronique . Le Bas-Bernardet . Stéphanie . Coulon . Flora . Mary . Caroline . Chenouard . Alexis . Hervouet . Jeremy . Minault . David . Nedellec . Steven . Renaudin . Karine . Vanhove . Bernard . Blancho . Gilles . Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection . Journal of the American Society of Nephrology . December 2016 . 27 . 12 . 3577–3588 . 10.1681/ASN.2015070774. free . 5118475 .
2. Zhang . T. . Gheorghe . B. . Sun . W. . Rybak . E. . Harris . D. . Sievert . E. . Burdorf . L. . Cheng . X. . Vanhove . B. . Azimzadeh . A. . Pierson . R. Iii . Effect of FR104, a Novel Anti-CD28 Fab, in Monkey Cardiac Allograft Transplantation.: Abstract# 1490 . Transplantation . 15 July 2014 . 98 . 33 . 0041-1337.
3. Poirier . N. . Mary . C. . Dilek . N. . Hervouet . J. . Minault . D. . Blancho . G. . Vanhove . B. . Preclinical Efficacy and Immunological Safety of FR104, an Antagonist Anti-CD28 Monovalent Fab′ Antibody . American Journal of Transplantation . October 2012 . 12 . 10 . 2630–2640 . 10.1111/j.1600-6143.2012.04164.x. free .
4. Poirier . N. . Dilek . N. . Mary . C. . Ville . S. . Coulon . F. . Branchereau . J. . Tillou . X. . Charpy . V. . Pengam . S. . Nerriere-Daguin . V. . Hervouet . J. . Minault . D. . Le Bas-Bernardet . S. . Renaudin . K. . Vanhove . B. . Blancho . G. . FR104, an Antagonist Anti-CD28 Monovalent Fab’ Antibody, Prevents Alloimmunization and Allows Calcineurin Inhibitor Minimization in Nonhuman Primate Renal Allograft . American Journal of Transplantation . February 2015 . 15 . 1 . 88–100 . 10.1111/ajt.12964. free .
5. Poirier . Nicolas . Blancho . Gilles . Hiance . Maryvonne . Mary . Caroline . Van Assche . Tim . Lempoels . Jos . Ramael . Steven . Wang . Weirong . Thepenier . Virginie . Braudeau . Cecile . Salabert . Nina . Josien . Regis . Anderson . Ian . Gourley . Ian . Soulillou . Jean-Paul . Coquoz . Didier . Vanhove . Bernard . First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28 . The Journal of Immunology . 15 December 2016 . 197 . 12 . 4593–4602 . 10.4049/jimmunol.1601538. free .