VAV3 explained

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.^[1]

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

VAV3 has been shown to interact with Grb2.^{[2] [3]}

See also

• Actin
• Cytoskeleton
• GTPase

Further reading

• Hobert O . SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin . Oncogene . 12 . 7 . 1577–81 . 1996 . 8622875 . vanc. Schilling JW . Beckerle MC . 3 . Ullrich . A . Jallal . B .
• Tamma SM . CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells . Blood . 90 . 4 . 1588–93 . 1997 . 9269777 . vanc. Chirmule N . Yagura H . 3 . Oyaizu . N . Kalyanaraman . V . Pahwa . S . 10.1182/blood.V90.4.1588 . free.
• Trenkle T . Non-stoichiometric reduced complexity probes for cDNA arrays . Nucleic Acids Res. . 26 . 17 . 3883–3891 . 1998 . 9705494 . 10.1093/nar/26.17.3883 . 147802 . vanc. Welsh J . Jung B . 3 . Mathieu-Daude . F . McClelland . M .
• Movilla N, Bustelo XR . Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins . Mol. Cell. Biol. . 19 . 11 . 7870–85 . 1999 . 10523675 . 10.1128/mcb.19.11.7870. 84867 .
• Trenkle T, McClelland M, Adlkofer K, Welsh J . Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors . Gene . 245 . 1 . 139–149 . 2000 . 10713454 . 10.1016/S0378-1119(00)00026-3 .
• Zeng L . Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation . Mol. Cell. Biol. . 20 . 24 . 9212–9224 . 2001 . 11094073 . 10.1128/MCB.20.24.9212-9224.2000 . 102179 . vanc. Sachdev P . Yan L . 3 . Chan . J. L. . Trenkle . T. . McClelland . M. . Welsh . J. . Wang . L.-H. .
• Inabe K . Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation . J. Exp. Med. . 195 . 2 . 189–200 . 2002 . 11805146 . 10.1084/jem.20011571 . 2193613 . vanc. Ishiai M . Scharenberg AM . 3 . Freshney . N . Downward . J . Kurosaki . T .
• Yabana N, Shibuya M . Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity . Oncogene . 21 . 50 . 7720–7729 . 2002 . 12400014 . 10.1038/sj.onc.1205927 . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Zakaria S . Differential regulation of TCR-mediated gene transcription by Vav family members . J. Exp. Med. . 199 . 3 . 429–434 . 2004 . 14757747 . 10.1084/jem.20031228 . 2211790 . vanc. Gomez TS . Savoy DN . 3 . McAdam . S . Turner . M . Abraham . RT . Billadeau . DD .
• Pearce AC . Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen . J. Biol. Chem. . 279 . 52 . 53955–53962 . 2005 . 15456756 . 10.1074/jbc.M410355200 . vanc. Senis YA . Billadeau DD . 3 . Turner . M . Watson . SP . Vigorito . E . free.
• Charvet C, Canonigo AJ, Billadeau DD, Altman A . Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76 . J. Biol. Chem. . 280 . 15 . 15289–15299 . 2005 . 15708849 . 10.1074/jbc.M500275200 . free .
• Lyons LS, Burnstein KL . Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity . Mol. Endocrinol. . 20 . 5 . 1061–1072 . 2006 . 16384856 . 10.1210/me.2005-0346 . 43049417 . free .
• Dong Z . Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer . Mol. Endocrinol. . 20 . 10 . 2315–2325 . 2006 . 16762975 . 10.1210/me.2006-0048 . vanc. Liu Y . Lu S . 3 . Wang . A . Lee . K . Wang . LH . Revelo . M . Lu . S . free .

Notes and References

1. Web site: Entrez Gene: VAV3 vav 3 oncogene.
2. Blagoev . Blagoy . Kratchmarova Irina . Ong Shao-En . Nielsen Mogens . Foster Leonard J . Mann Matthias . March 2003 . A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling . Nat. Biotechnol. . 21 . 3 . 315–318 . 1087-0156. 12577067 . 10.1038/nbt790 . 26838266 .
3. Zeng . L . Sachdev P . Yan L . Chan J L . Trenkle T . McClelland M . Michael McClelland (academic) . Welsh J . Wang L H . December 2000 . Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation . Mol. Cell. Biol. . 20 . 24 . 9212–9224 . 0270-7306. 11094073 . 10.1128/MCB.20.24.9212-9224.2000 . 102179 .