VAT1 explained

Synaptic vesicle membrane protein VAT-1 homolog is a protein that in humans is encoded by the VAT1 gene.^{[1] [2] [3]}

Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.

In melanocytic cells VAT1 gene expression may be regulated by MITF.^[4]

See also

• Acetylcholine, the neurotransmitter in cholinergic synaptic vesicles

Further reading

• Miki Y, Swensen J, Shattuck-Eidens D, etal . A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. . Science . 266 . 5182 . 66–71 . 1994 . 7545954 . 10.1126/science.7545954 . 1994Sci...266...66M .
• Harshman K, Bell R, Rosenthal J, etal . Comparison of the positional cloning methods used to isolate the BRCA1 gene. . Hum. Mol. Genet. . 4 . 8 . 1259–66 . 1995 . 7581362 . 10.1093/hmg/4.8.1259 .
• Friedman LS, Ostermeyer EA, Lynch ED, etal . The search for BRCA1. . Cancer Res. . 54 . 24 . 6374–82 . 1995 . 7987831 .
• Matoba R, Okubo K, Hori N, etal . The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. . Gene . 146 . 2 . 199–207 . 1994 . 8076819 . 10.1016/0378-1119(94)90293-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE, etal . 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors . Genomics . 25 . 1 . 256–63 . Jul 1995 . 7774926 . 10.1016/0888-7543(95)80133-7 . free .
2. Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC . Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1 . Genome Res . 6 . 11 . 1029–49 . Feb 1997 . 8938427 . 10.1101/gr.6.11.1029 . free .
3. Web site: Entrez Gene: VAT1 vesicle amine transport protein 1 homolog (T. californica).
4. Hoek KS, Schlegel NC, Eichhoff OM, etal . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell Melanoma Res. . 21 . 6 . 665–76 . 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . 24698373 . free .