VANGL2 explained

VANGL planar cell polarity protein 2 is a protein that in humans is encoded by the VANGL2 gene.^[1]

Function

The protein encoded by the VANGL2 gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011].

Further reading

• Erdal E, Erdal C, Bulut G, Kunter I, Kir M, Atabey N, Açikel U . Mutation analysis of the Vangl2 coding region revealed no common cause for Tetralogy of Fallot . J. Int. Med. Res. . 35 . 6 . 867–72 . 2007 . 18034999 . 10.1177/147323000703500614 . 28747920 .
• Cantrell VA, Jessen JR . The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion . Cancer Lett. . 287 . 1 . 54–61 . January 2010 . 19577357 . 10.1016/j.canlet.2009.05.041 .
• Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CH . The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis . Hum. Mol. Genet. . 19 . 11 . 2251–67 . June 2010 . 20223754 . 2865378 . 10.1093/hmg/ddq104 .
• Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY . VANGL2 mutations in human cranial neural-tube defects . N. Engl. J. Med. . 362 . 23 . 2232–5 . June 2010 . 20558380 . 10.1056/NEJMc0910820 . free .
• Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY . VANGL2 mutations in human cranial neural-tube defects . N. Engl. J. Med. . 362 . 23 . 2232–5 . June 2010 . 20558380 . 10.1056/NEJMc0910820 . free .
• Kibar Z, Salem S, Bosoi CM, Pauwels E, De Marco P, Merello E, Bassuk AG, Capra V, Gros P . Contribution of VANGL2 mutations to isolated neural tube defects . Clin. Genet. . 80 . 1 . 76–82 . July 2011 . 20738329 . 3000889 . 10.1111/j.1399-0004.2010.01515.x .
• Iliescu A, Gravel M, Horth C, Kibar Z, Gros P . Loss of membrane targeting of Vangl proteins causes neural tube defects . Biochemistry . 50 . 5 . 795–804 . February 2011 . 21142127 . 10.1021/bi101286d .
• Guo Y, Zanetti G, Schekman R . A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network . eLife . 2 . e00160 . January 2013 . 23326640 . 3539332 . 10.7554/eLife.00160 . free .
• Piazzi G, Selgrad M, Garcia M, Ceccarelli C, Fini L, Bianchi P, Laghi L, D'Angelo L, Paterini P, Malfertheiner P, Chieco P, Boland CR, Bazzoli F, Ricciardiello L . Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers . Br. J. Cancer . 108 . 8 . 1750–6 . April 2013 . 23579212 . 3668461 . 10.1038/bjc.2013.142 .

Notes and References

1. Web site: Entrez Gene: VANGL planar cell polarity protein 2. 2018-07-05.