V451 vaccine explained

Type:vaccine
Target:SARS-CoV-2
Vaccine Type:protein
Legal Status:Terminated
Routes Of Administration:Intramuscular
Synonyms:SARS-CoV-2 Sclamp

V451 was a COVID-19 vaccine candidate developed by the University of Queensland and the Australian pharmaceutical company CSL Limited. The vaccine candidate used the University of Queensland's molecular clamp technology[1] and the MF59 adjuvant.[2]

Description

V451 is a protein subunit vaccine. As part of the vaccine's design, researchers added "a fragment of one protein found on the HIV virus"[3] as a "ground-breaking molecular clamp technology".[4]

Terminated trial

The development of the vaccine was cancelled on 11 December 2020 during its Phase I trial, after a number of trial participants were found to give false positive test results for HIV antibodies when they did not in fact have HIV.[5] [6] This was due to the HIV virus fragment used as a molecular clamp leading to "a partial antibody response" to HIV. This is an undesirable outcome as it will interfere with future HIV screening tests for affected participants.[7]

Nine days prior to the termination, on 2 December, the first emergency use authorisation had been granted to a COVID-19 vaccine; the Pfizer–BioNTech COVID-19 vaccine in the United Kingdom.[8] Following the termination of V451, vaccine production capacity by CSL Limited was diverted to the Oxford–AstraZeneca COVID-19 vaccine.[9]

Notes and References

  1. Web site: UQ-CSL V451 Vaccine. 2020-12-11. www.precisionvaccinations.com. en-US. 2020-12-19. https://web.archive.org/web/20201219104227/https://www.precisionvaccinations.com/vaccines/uq-csl-v451-vaccine. dead.
  2. News: Meneguzzi J . Why a COVID-19 vaccine could further imperil deep-sea sharks . https://web.archive.org/web/20201113155426/https://www.nationalgeographic.com/animals/2020/11/why-covid-19-vaccine-further-imperil-deep-sea-sharks/ . dead . November 13, 2020 . National Geographic . 13 November 2020.
  3. News: ABC News. Slezak, Michael. How the UQ coronavirus vaccine induced false-positive HIV test results and why scientists were prepared . 11 December 2020.
  4. News: Smyth J . Australia abandons local Covid vaccine over HIV test concerns . Financial Times . 11 December 2020.
  5. News: 2020-12-11. Covid: Australian vaccine abandoned over false HIV response. en-GB. BBC News. 2020-12-11.
  6. News: 2020-12-10. BRIEF-CSL Says Will Not Progress UQ-CSL V451 COVID-19 Vaccine Candidate To Phase 2/3 Clinical Trials. en. Reuters. 2020-12-11.
  7. News: Australia ends local COVID vaccine trials due to HIV false positives . Deutsche Welle . 11 December 2020.
  8. Web site: UK medicines regulator gives approval for first UK COVID-19 vaccine . 2 December 2020 . Medicines and Healthcare products Regulatory Agency (MHRA) . 2 December 2020 . 2 December 2020 . https://web.archive.org/web/20201202101605/https://www.gov.uk/government/news/uk-medicines-regulator-gives-approval-for-first-uk-covid-19-vaccine . live .
  9. Web site: COVID-19 Update. 2021-01-31. www.csl.com. en-US.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "V451 vaccine".

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