V-set and immunoglobulin domain containing 4 explained

V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene.^[1]

Function

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.

Further reading

• Helmy KY, Katschke KJ, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M . CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens . Cell . 124 . 5 . 915–27 . 2006 . 16530040 . 10.1016/j.cell.2005.12.039 . free .

Notes and References

1. Web site: Entrez Gene: V-set and immunoglobulin domain containing 4. 2016-06-13.