| Honorific-Prefix: | General |
| Víctor Casco de Mendoza | |
| Office1: | Lieutenant Governor of Buenos Aires |
| Term Start1: | 1606 |
| Term End1: | 1607 |
| Predecessor1: | Tomás de Garay |
| Successor1: | Simón de Valdez |
| Order3: | Mayor of Buenos Aires |
| Term Start3: | 1603 |
| Term End3: | 1604 |
| Predecessor3: | Juan Ramírez de Abreu |
| Successor3: | Francisco Muñoz |
| Order4: | Mayor of Buenos Aires |
| Term Start4: | 1610 |
| Term End4: | 1611 |
| Predecessor4: | Pedro de Izarra |
| Successor4: | Francisco de Salas Reynoso |
| Order5: | Mayor of Buenos Aires |
| Term Start5: | 1615 |
| Term End5: | 1616 |
| Predecessor5: | Juan de Vergara |
| Successor5: | Pedro de Izarra |
| Birth Date: | 1560 |
| Birth Place: | Asuncion, Paraguay |
| Death Date: | c.1615 |
| Death Place: | Buenos Aires, Argentina |
| Spouse: | Luisa de Valderrama |
| Signature: | Víctor Casco de Mendoza firma.png |
| Branch: | Spanish Army |
| Rank: | General |
Víctor Casco de Mendoza (1560-1600s) was a Spanish nobleman. He held political posts during the Viceroyalty of Peru, serving as alcalde, regidor and lieutenant governor of Buenos Aires[1] and Asuncion.[2]
He was born in Asuncion, the son of Gonzalo Casco, a Spanish conquistador, born in Asturias, and María de Mendoza Irala, belonging to a noble family of Asuncion. He was married to Luisa de Valderrama, daughter of Juan de Fustes and Beatriz Ramírez.[3] Víctor Casco de Mendoza was one of the sixty-three neighbors who accompanied Juan de Garay in the second foundation of Buenos Aires.[4]