| Urupá River | |
| Source1 Location: | Pacaás Novos National Park, Rondônia state |
| Mouth Location: | Ji-Paraná |
| Mouth Coordinates: | -10.8897°N -61.9473°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Urupá River is a river of Rondônia state in western Brazil. It is a left tributary of the Ji-Paraná River.
Its source is in the Pacaás Novos National Park.