| guanylate cyclase activator 2B (uroguanylin) | |
| Hgncid: | 4683 |
| Symbol: | GUCA2B |
| Entrezgene: | 2981 |
| Omim: | 601271 |
| Refseq: | NM_007102 |
| Uniprot: | Q16661 |
| Chromosome: | 1 |
| Arm: | p |
| Band: | 34 |
| Locussupplementarydata: | -p33 |
Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. By agonizing this guanylyl cyclase receptor, uroguanylin and guanylin cause intestinal secretion of chloride and bicarbonate to dramatically increase; this process is helped by the second messenger cGMP.[1] Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.
In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[2] [3] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[4]