Uri Alon Explained

Uri Alon
Birth Date:[1]
Workplaces:Weizmann Institute of Science
Princeton University
Alma Mater:Hebrew University of Jerusalem
Weizmann Institute of Science
Doctoral Advisor:David Mukamel[2]
Doctoral Students:Ron Milo
Known For:Network motifs
Awards:Overton Prize (2004)

Uri Alon (Hebrew: אורי אלון; born 1969) is a Professor and Systems Biologist at the Weizmann Institute of Science.[3] His highly cited research investigates gene expression,[4] network motifs[5] [6] and the design principles of biological networks[7] in Escherichia coli and other organisms using both computational biology and traditional experimental wet laboratory techniques.

Education

Alon earned his bachelor's and master's degrees from the Hebrew University of Jerusalem and his Ph.D. in Theoretical Physics[2] [8] from the Weizmann Institute of Science.

Career

After having his interest in biology sparked, Alon headed to Princeton University for his postdoctoral work in experimental biology. He returned to the Weizmann Institute as a professor.

Alon features in several popular videos on YouTube such as Sunday at the Lab (with Michael Elowitz) and How to Give a Good Talk. As of 2011, he is the author of the most highly bookmarked scientific paper on CiteULike[9] How To Choose a Good Scientific Problem[10] and How to Build a Motivated Research Group.[11]

In 2021 he was appointed visiting professor in the bioengineering department of Stanford University. He is a member of the IBS Biomedical Mathematics Group.[12]

Research

Uri Alon significantly contributed to our understanding of gene regulatory networks and generalized the term network motif in 2002.[13] [14] [15]

Together with his team, he reunited different theories of endocrine feedback loops by introducing the closely related concepts of dynamical compensation and autoimmune surveillance of hypersecreting mutants (ASHM).[16] [17] [18] The theories are able to explain a plethora of phenomena ranging from circannual endocrine rhythms[19] over type 2 diabetes[20] and other common endocrine disorders[21] to alcohol addiction[22] and age-related diseases.[23]

Awards

In 2004 Alon was awarded the Overton Prize for "outstanding accomplishment by a scientist in the early to mid stage of his or her career" by the International Society for Computational Biology. Alon has also been awarded:

Notes and References

  1. Web site: Wis-Find: Author Search Results. weizmann.ac.il.
  2. Alon . U. . Evans . M. . Hinrichsen . H. . Mukamel . D. . Roughening Transition in a One-Dimensional Growth Process . 10.1103/PhysRevLett.76.2746 . cond-mat/9512069. Physical Review Letters . 76 . 15 . 2746–2749 . 1996 . 10060778. 1996PhRvL..76.2746A . 26730428 .
  3. Web site: Homepage - Uri Alon. weizmann.ac.il.
  4. Alon . U. . Barkai . N. . Notterman . D. A. . Gish . K. . Ybarra . S. . Mack . D. . Levine . A. J. . Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays . 10.1073/pnas.96.12.6745 . Proceedings of the National Academy of Sciences . 96 . 12 . 6745–6750 . 1999 . 10359783. 21986. 1999PNAS...96.6745A . free .
  5. Milo . R. . Shen-Orr . S. . Itzkovitz . S. . Kashtan . N. . Chklovskii . D. . Alon . U. . Network Motifs: Simple Building Blocks of Complex Networks . 10.1126/science.298.5594.824 . Science . 298 . 5594 . 824–827 . 2002 . 12399590. 2002Sci...298..824M . 10.1.1.225.8750 . 9884096 .
  6. Shen-Orr . S. S. . Milo . R. . Mangan . S. . Alon . U. . Network motifs in the transcriptional regulation network of Escherichia coli . Nature Genetics . 31 . 1 . 64–68 . 2002 . 11967538 . 10.1038/ng881. 2180121 . free .
  7. Book: Uri Alon . An introduction to systems biology: design principles of biological circuits . Chapman & Hall/CRC . Boca Raton . 2007 . 978-1-58488-642-6 .
  8. Web site: arXiv.org Search. arxiv.org.
  9. Web site: CiteULike CiteGeist: Popular Papers . 2011-06-09.
  10. Alon . U. . How to Choose a Good Scientific Problem . 10.1016/j.molcel.2009.09.013 . Molecular Cell . 35 . 6 . 726–728 . 2009 . 19782018. 2020-09-16. free .
  11. Alon . U. . How to Build a Motivated Research Group . 10.1016/j.molcel.2010.01.011 . Molecular Cell . 37 . 2 . 151–152 . 2010 . 20122395. 2020-09-16. free .
  12. Web site: Uri Alon . 2024-05-26 . Biomedical Mathematics Group . en-US.
  13. R. Milo, S. Shen-Orr, S. Itzkovitz, N. Kashtan, D. Chklovskii, U. Alon: Network motifs: simple building blocks of complex networks, Science 298, 2002, S. 824–827
  14. S. Shen-Orr, R. Milo, S. Mangan, U. Alon: Network motifs in the transcriptional regulation network of Escherichia coli, Nature Genetics 31, 2002,: 64–68
  15. Alon . Uri . Network motifs: theory and experimental approaches . Nature Reviews Genetics . June 2007 . 8 . 6 . 450–461 . 10.1038/nrg2102. 17510665 . 7169406 .
  16. Karin . O . Swisa . A . Glaser . B . Dor . Y . Alon . U . Dynamical compensation in physiological circuits. . Molecular Systems Biology . 8 November 2016 . 12 . 11 . 886 . 10.15252/msb.20167216 . 27875241. 5147051 .
  17. Maimon . L . Milo . T . Moyal . RS . Mayo . A . Danon . T . Bren . A . Alon . U . Timescales of Human Hair Cortisol Dynamics. . iScience . 26 August 2020 . 23 . 9 . 101501 . 10.1016/j.isci.2020.101501 . 32911331. 7490542 . 2020iSci...23j1501M .
  18. Korem Kohanim . Y . Tendler . A . Mayo . A . Friedman . N . Alon . U . Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants. . Immunity . 19 May 2020 . 52 . 5 . 872–884.e5 . 10.1016/j.immuni.2020.04.022 . 32433950. 7237888 .
  19. Tendler . A . Bar . A . Mendelsohn-Cohen . N . Karin . O . Korem Kohanim . Y . Maimon . L . Milo . T . Raz . M . Mayo . A . Tanay . A . Alon . U . Hormone seasonality in medical records suggests circannual endocrine circuits. . Proceedings of the National Academy of Sciences of the United States of America . 16 February 2021 . 118 . 7 . e2003926118 . 10.1073/pnas.2003926118 . 33531344. 7896322 . 2021PNAS..11803926T . free .
  20. Karin . O . Alon . U . Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits. . Molecular Systems Biology . 26 June 2017 . 13 . 6 . 933 . 10.15252/msb.20177599 . 28652282. 5488663 .
  21. Karin . O . Raz . M . Tendler . A . Bar . A . Korem Kohanim . Y . Milo . T . Alon . U . A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks. . Molecular Systems Biology . July 2020 . 16 . 7 . e9510 . 10.15252/msb.20209510 . 32672906. 7364861 .
  22. Karin . O . Raz . M . Alon . U . An opponent process for alcohol addiction based on changes in endocrine gland mass. . iScience . 19 March 2021 . 24 . 3 . 102127 . 10.1016/j.isci.2021.102127 . 33665551. 7903339 . 2021iSci...24j2127K .
  23. Katzir . I . Adler . M . Karin . O . Mendelsohn-Cohen . N . Mayo . A . Alon . U . Senescent cells and the incidence of age-related diseases. . Aging Cell . March 2021 . 20 . 3 . e13314 . 10.1111/acel.13314 . 33559235. 7963340 .
  24. Web site: Uri Alon. f1000.com.
  25. http://www.radcliffe.edu/fellowships/fellows_2010ualon.aspx Radcliffe Fellows
  26. Web site: 2014 HFSP Nakasone Award goes to Uri Alon. hfsp.org.

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