Urea carboxylase explained
| urea carboxylase |
| Ec Number: | 6.3.4.6 |
| Cas Number: | 9058-98-4 |
| Go Code: | 0004847 |
In enzymology, a urea carboxylase is an enzyme that catalyzes the chemical reaction
ATP + urea + HCO3-
ADP + phosphate + urea-1-carboxylate
The 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate (allophanate).
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is urea:carbon-dioxide ligase (ADP-forming). This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, biotin.
See also
References
- Book: Roon RJ . Levenberg B . Metabolism of Amino Acids and Amines Part A . [37a] ATP: Urea amidolyase (ADP) (Candida utilis) . 1970 . 17A . 317 - 324 . 10.1016/0076-6879(71)17204-7. Methods in Enzymology . 9780121818746 .
- Roon RJ, Levenberg B . 1972 . Urea amidolyase. I. Properties of the enzyme from Candida utilis . J. Biol. Chem. . 247 . 4107 - 13 . 4556303 . 13 . 10.1016/S0021-9258(19)45046-1 . free .
- Sumrada RA, Cooper TG . 1982 . Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast . J. Biol. Chem. . 257 . 9119 - 27 . 6124544 . 15 . 10.1016/S0021-9258(18)34251-0 . free .
- Kanamori T, Kanou N, Atomi H, Imanaka T . 2004 . Enzymatic characterization of a prokaryotic urea carboxylase . J. Bacteriol. . 186 . 2532 - 9 . 15090492 . 10.1128/JB.186.9.2532-2539.2004 . 9 . 387783 .
