| Upía River | |
| Source1 Location: | Lake Tota |
| Mouth Location: | Meta River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Colombia |
Upía River, a river in Colombia originating at Lake Tota (5°29'31" N, 72°56'04" W), is a tributary of the Meta River flowing into the Orinoco River basin.