| Honorific Prefix: | Rai Bahadur Sir |
| Upendranath Brahmachari | |
| Birth Date: | 1873 12, df=yes |
| Birth Place: | Sardanga, Purbasthali, Bengal Presidency, British India |
| Death Place: | Calcutta, Bengal Presidency, British India |
| Children: | Phanindra Nath, Brahmachari Nirmal, Kumar Brahmachari |
| Spouse: | Nani Bala Devi |
| Fields: | Medicine, Physician |
| Doctoral Advisor: | Sir Gerald Bomford |
Rai Bahadur Sir Upendranath Brahmachari (bn|উপেন্দ্রনাথ ব্রহ্মচারী; 19 December 1873 – 6 February 1946) was a prominent Indian physician and scientist.[1] In 1922, he synthesised urea-stibamine (carbostibamide) and demonstrated its effectiveness in treating kala-azar (visceral leishmaniasis).
Brahmachari was born on 19 December 1873 in Sardanga village near Purbasthali, District Burdwan, West Bengal, India. His father, Nilmony Brahmachari, was a physician in East Indian Railways and his mother was Saurabh Sundari Devi. He completed his early education from Eastern Railways Boys' High School in Jamalpur, Bihar. In 1893, he earned a BA degree from Hooghly Mohsin College with honours in Mathematics and Chemistry. Following this, Brahmachari pursued further studies in Medicine and Higher Chemistry. In 1894, he obtained a master’s degree from Presidency College, Kolkata. In 1898, he married Nani Bala Devi.
In the 1900 M.B. Examination of the University of Calcutta, Brahmachari excelled – first in Medicine and then in Surgery – for which he received the Goodeve and Macleod awards. He earned an MD degree in 1902 and a PhD in 1904 for his research paper on "Studies in Haemolysis", both from the University of Calcutta.[2]
In 1922, Brahmachari discovered a new form of leishmaniasis, which he called dermal leishmanoid. The condition was marked by the appearance of sudden eruptions on the patients’ faces without fever or other symptoms. Brahmachari observed it in partially cured cases of kala-azar as well as in individuals who had no prior history of the disease at all.[3] It has since been termed as post-kala-azar dermal leishmaniasis.
Brahmachari was awarded the title of Rai Bahadur and the Kaisar-i-Hind Gold Medal, 1st Class, by the Governor General Lord Lytton (1924).[4] In 1934, he was conferred a knighthood by the British Government.[5]
Brahmachari was a nominee for the Nobel Prize twice in 1929[6] and five times in 1942[7] in the category of physiology or medicine although he never received it. Some sources suggest that his ethinicity may have influenced the Nobel committee’s decision.[8] He served as president of the 23rd session of the Indian Science Congress in Indore (1936) and was also president of the Indian Chemical Society in Calcutta (1936). Brahmachari was honoured with fellowships from the Royal Society of Medicine, London, and the Indian National Science Academy. He was the President of the Asiatic Society of Bengal for two years (1928–29)[9] and also the vice-chairman of the board of Trustees of the Indian Museum.[10]
Dr. Brahmachari had over 144 Scientific Publications and had written several books, a partial list of which include: