| University High School of Science and Engineering | |
| Type: | Public High School |
| Category: | Magnet STEM High School |
| Affiliation: | University of Hartford |
| Principal: | Sean Tomany |
| Faculty: | ~45 |
| Teaching Staff: | ~35 |
| Enrollment: | ~400 |
| Grades: | 9-12 |
| Streetaddress: | 351 Mark Twain Dr |
| City: | Hartford |
| State: | Connecticut |
| Zipcode: | 06112 |
| Country: | United States |
| Coordinates: | 41.797°N -72.7095°W |
| Ceeb: | 070326 |
| District: | Hartford Public Schools |
| Colors: | Black and red |
| Nickname: | UHSSE |
| Mascot: | Hawks |
| Newspaper: | University Times |
| Conference: | Capitol Region Athletic League |
University High School of Science and Engineering (UHSSE) is a Science, Technology, Engineering, and Math magnet high school located in Hartford, Connecticut. This public school was started in 2004, with a small body of faculty, headed by principal Dr Elizabeth Colli, and a freshman class of one hundred students.